The study of race/ethnicity in relation to health outcomes and health disparities is of great importance in medicine. This is as true in the field of osteoporosis as it is in others, and it comes into sharp focus when the question of population-specific reference data for bone densitometry arises. Race/ethnicity can be viewed as both an ecosocial construct and as a biomedical concept. Whether or not, and how, to use race/ethnicity in fracture assessment potentially places these two paradigms in opposition. In this article, some of the issues that need to be considered to develop a rational approach to reference data selection and a globally acceptable measure of fracture risk are reviewed. Race/ethnicity is often a proxy for other disease-related risk factors. Understanding fundamental risk factors goes beyond the language of race/ethnicity.