Free radical-scavenging delta-lactones from Boletus calopus

Planta Med. 2006 Dec;72(15):1431-2. doi: 10.1055/s-2006-951722. Epub 2006 Nov 7.

Abstract

The methanol extracts from the fruiting body of the mushroom Boletus calopus showed free radical-scavenging activity. Bioactivity-guided fractionation of the methanol extracts led to a new hydroxylated calopin named calopin B, along with the known delta-lactones calopin and cyclocalopin A. The structure of the new calopin analogue was elucidated by spectroscopic methods. All compounds showed potent free radical-scavenging activity against superoxide, DPPH, and ABTS radicals with IC (50) values of 1.2 - 5.4 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales*
  • Benzothiazoles / chemistry
  • Biphenyl Compounds
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Free Radical Scavengers / therapeutic use
  • Humans
  • Inhibitory Concentration 50
  • Lactones / administration & dosage
  • Lactones / chemistry
  • Lactones / pharmacology
  • Lactones / therapeutic use
  • Phytotherapy*
  • Picrates / chemistry
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Structure-Activity Relationship
  • Sulfonic Acids / chemistry
  • Superoxides / chemistry

Substances

  • Benzothiazoles
  • Biphenyl Compounds
  • Free Radical Scavengers
  • Lactones
  • Picrates
  • Plant Extracts
  • Sulfonic Acids
  • Superoxides
  • 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
  • 1,1-diphenyl-2-picrylhydrazyl