Abstract
The methanol extracts from the fruiting body of the mushroom Boletus calopus showed free radical-scavenging activity. Bioactivity-guided fractionation of the methanol extracts led to a new hydroxylated calopin named calopin B, along with the known delta-lactones calopin and cyclocalopin A. The structure of the new calopin analogue was elucidated by spectroscopic methods. All compounds showed potent free radical-scavenging activity against superoxide, DPPH, and ABTS radicals with IC (50) values of 1.2 - 5.4 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales*
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Benzothiazoles / chemistry
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Biphenyl Compounds
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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Free Radical Scavengers / therapeutic use
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Humans
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Inhibitory Concentration 50
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Lactones / administration & dosage
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Lactones / chemistry
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Lactones / pharmacology
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Lactones / therapeutic use
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Phytotherapy*
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Picrates / chemistry
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Structure-Activity Relationship
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Sulfonic Acids / chemistry
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Superoxides / chemistry
Substances
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Benzothiazoles
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Biphenyl Compounds
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Free Radical Scavengers
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Lactones
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Picrates
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Plant Extracts
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Sulfonic Acids
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Superoxides
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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1,1-diphenyl-2-picrylhydrazyl