Effects of Yiweining Recipe on expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in ectopic endometrium of rats with endometriosis

Zhong Xi Yi Jie He Xue Bao. 2006 Nov;4(6):634-8. doi: 10.3736/jcim20060619.

Abstract

Objective: To explore the effects of Yiweining Recipe (YWNR), a compound Chinese herbal medicine, on expressions of metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) mRNAs in rats with endometriosis (EM).

Methods: Operational self-transplantation was applied in establishing the rat models. Detection of MMP-2 and COX-2 mRNAs was conducted with hybridization in situ.

Results: There were significant differences in the expressions of MMP-2 and COX-2 mRNAs between the untreated group and the high-dose YWNR-treated group. YWNR could reduce the expressions of MMP-2 and COX-2 mRNAs.

Conclusion: YWNR can treat EM through reducing the positive expressions of MMP-2 and COX-2 mRNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclooxygenase 2 / genetics*
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use*
  • Endometriosis / drug therapy*
  • Endometriosis / enzymology
  • Endometriosis / genetics
  • Female
  • Gene Expression Regulation, Enzymologic / drug effects
  • Matrix Metalloproteinase 2 / genetics*
  • Phytotherapy*
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Uterine Diseases / drug therapy*
  • Uterine Diseases / enzymology
  • Uterine Diseases / genetics

Substances

  • Drugs, Chinese Herbal
  • RNA, Messenger
  • yiweining
  • Cyclooxygenase 2
  • Matrix Metalloproteinase 2