Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa

Br J Cancer. 2006 Dec 4;95(11):1525-8. doi: 10.1038/sj.bjc.6603441. Epub 2006 Oct 31.

Abstract

The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Colorectal Neoplasms / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • ErbB Receptors / metabolism*
  • Female
  • Humans
  • Intestinal Mucosa / metabolism*
  • Male
  • RNA, Messenger / analysis
  • Rectum / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • RNA, Messenger
  • ErbB Receptors