Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production

Mauricio Berriel Diaz; Ulrike Lemke; Stephan Herzig

doi:10.1016/j.cmet.2006.10.005

Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production

Cell Metab. 2006 Nov;4(5):339-40. doi: 10.1016/j.cmet.2006.10.005.

Authors

Mauricio Berriel Diaz¹, Ulrike Lemke, Stephan Herzig

Affiliation

¹ Emmy-Noether Research Group, Molecular Metabolic Control A170, German Cancer Research Center Heidelberg, 69120 Heidelberg, Germany.

PMID: 17084708
DOI: 10.1016/j.cmet.2006.10.005

Abstract

Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions.

Publication types

Review

MeSH terms

DNA-Binding Proteins / physiology*
Diabetes Mellitus, Type 2 / metabolism*
Glucose / biosynthesis*
Humans
Liver / metabolism*
Nuclear Receptor Subfamily 4, Group A, Member 1
Receptors, Cytoplasmic and Nuclear / physiology*
Receptors, Steroid / physiology*
Transcription Factors / physiology*

Substances

DNA-Binding Proteins
NR4A1 protein, human
Nuclear Receptor Subfamily 4, Group A, Member 1
Receptors, Cytoplasmic and Nuclear
Receptors, Steroid
Transcription Factors
Glucose