Stroke risk factor, pattern and outcome in patients with cancer

Acta Neurol Scand. 2006 Dec;114(6):378-83. doi: 10.1111/j.1600-0404.2006.00709.x.

Abstract

Objective: To investigate risk factors, stroke pattern and outcome in stroke patients with cancer.

Methods: A retrospective review of all stroke patients with cancer (n = 69) admitted to Bankstown-Lidcombe Hospital, Sydney, Australia, between January 1999 and December 2004 was conducted, and comparison made to age- and gender-matched non-cancer stroke patients admitted to the same hospital during the same period.

Results: Vascular risk factors did not significantly differ between cancer and non-cancer groups. There was a trend towards greater risk of intracerebral haemorrhage in the cancer group vs the non-cancer group. Previous deep vein thrombosis was more common, and prothrombin time and activated partial thromboplastin time were prolonged in the cancer group vs the non-cancer group. More patients died in hospital in the cancer group vs the non-cancer group.

Conclusions: Coagulation disorders are more likely to be seen in stroke patients with cancer, and patients with cancer have a higher in-hospital post-stroke mortality.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Australia
  • Blood Coagulation Tests
  • Brain Ischemia / blood
  • Brain Ischemia / complications
  • Case-Control Studies
  • Female
  • Humans
  • Intracranial Hemorrhages / blood
  • Intracranial Hemorrhages / complications
  • Male
  • Neoplasms / blood
  • Neoplasms / complications*
  • Neoplasms / pathology
  • Risk Factors
  • Stroke / etiology*
  • Stroke / mortality
  • Stroke / therapy
  • Treatment Outcome