Based on stable isotope measurements, Ghosh et al. (Reports, 27 January 2006, p. 511) concluded that the Bolivian Altiplano uplifted 3 to 4 kilometers between approximately 10.3 and approximately 6.7 million years ago as a result of gravitational loss of dense lithosphere. This result stands at odds with current geological knowledge of the Central Andes, and we propose a test for the reliability of the paleoaltimetry method.