A mitotic role for BRCA1/BARD1 in tumor suppression?

Cell. 2006 Nov 3;127(3):453-5. doi: 10.1016/j.cell.2006.10.020.

Abstract

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.

Publication types

  • Comment

MeSH terms

  • Animals
  • BRCA1 Protein / genetics
  • BRCA1 Protein / metabolism*
  • Cell Cycle Proteins / metabolism
  • Cell Extracts / chemistry
  • Dimerization
  • Female
  • HeLa Cells
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Neoplasm Proteins / metabolism
  • Nuclear Proteins / metabolism
  • Oocytes / chemistry
  • Phosphoproteins / metabolism
  • Spindle Apparatus / metabolism*
  • Tubulin / metabolism
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*
  • Xenopus / metabolism
  • Xenopus Proteins / metabolism
  • ran GTP-Binding Protein / metabolism*

Substances

  • BRCA1 Protein
  • Cell Cycle Proteins
  • Cell Extracts
  • Hmmr protein, Xenopus
  • Microtubule-Associated Proteins
  • NUMA1 protein, Xenopus
  • Neoplasm Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • TPX2 protein, Xenopus
  • Tubulin
  • Tumor Suppressor Proteins
  • Xenopus Proteins
  • BARD1 protein, human
  • Ubiquitin-Protein Ligases
  • ran GTP-Binding Protein