Abstract
The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.
MeSH terms
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Animals
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BRCA1 Protein / genetics
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BRCA1 Protein / metabolism*
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Cell Cycle Proteins / metabolism
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Cell Extracts / chemistry
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Dimerization
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Female
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HeLa Cells
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Humans
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Microtubule-Associated Proteins / metabolism
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Neoplasm Proteins / metabolism
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Nuclear Proteins / metabolism
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Oocytes / chemistry
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Phosphoproteins / metabolism
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Spindle Apparatus / metabolism*
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Tubulin / metabolism
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / metabolism*
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / metabolism*
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Xenopus / metabolism
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Xenopus Proteins / metabolism
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ran GTP-Binding Protein / metabolism*
Substances
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BRCA1 Protein
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Cell Cycle Proteins
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Cell Extracts
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Hmmr protein, Xenopus
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Microtubule-Associated Proteins
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NUMA1 protein, Xenopus
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Neoplasm Proteins
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Nuclear Proteins
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Phosphoproteins
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TPX2 protein, Xenopus
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Tubulin
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Tumor Suppressor Proteins
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Xenopus Proteins
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BARD1 protein, human
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Ubiquitin-Protein Ligases
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ran GTP-Binding Protein