Abstract
The cardiac protein profiles of spontaneously hypertensive and renovascularly hypertensive hypertrophy showed a significant alteration compared with normal hearts. Most proteins with significant modulations in their expressions belong to the category of metabolic and stress-related proteins. Among these proteins, glutathione-S-transferase mu2 and short-chain acyl-CoA dehydrogenase may be two candidate proteins associated with left ventricular hypertrophy in spontaneously hypertensive rats.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acyl-CoA Dehydrogenase / genetics
-
Acyl-CoA Dehydrogenase / metabolism
-
Amino Acid Sequence
-
Animals
-
Blood Pressure
-
Cardiomegaly / genetics*
-
Disease Models, Animal
-
Electrocardiography
-
Electrophoresis, Gel, Two-Dimensional
-
Glutathione Transferase / genetics
-
Hypertension, Renovascular / genetics*
-
Molecular Sequence Data
-
Proteins / genetics*
-
Proteins / isolation & purification
-
Proteome*
-
RNA, Messenger / genetics
-
RNA, Messenger / isolation & purification
-
Rats
-
Rats, Inbred SHR
-
Rats, Inbred Strains
-
Reverse Transcriptase Polymerase Chain Reaction
-
Ventricular Dysfunction, Left
Substances
-
Proteins
-
Proteome
-
RNA, Messenger
-
Acyl-CoA Dehydrogenase
-
Glutathione Transferase