Structures of new cucurbitane-type triterpenes and glycosides, karavilagenins and karavilosides, from the dried fruit of Momordica charantia L. in Sri Lanka

Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1545-50. doi: 10.1248/cpb.54.1545.

Abstract

Three new cucurbitane-type triterpene called karavilagenins A, B, and C and five new cucurbitane-type triterpene glycosides called karavilosides I, II, III, IV, and V were isolated from the dried fruit of Sri Lanka Momordica charantia L. (Cucurbitaceae) together with two known cucurbitane-type triterpenes, 19(R)-methoxy-5beta,19-epoxycucurbita-6,23-dien-3beta,25-diol and 5,19-epoxycucurbita-6,23-diene-3,25-diol, and nine known cucurbitane-type triterpene glycosides, goyaglycosides-b, -c, and -d, and momordicosides F1, F2, G, I, K, and L. The structures of karavilagenins and karavilosides were elucidated on the basis of chemical and physicochemical evidence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fruit / chemistry*
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Molecular Conformation
  • Momordica charantia / chemistry*
  • Sri Lanka
  • Stereoisomerism
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification

Substances

  • Glycosides
  • Triterpenes
  • cucurbitane
  • karavilagenin A
  • karavilagenin B
  • karaviloside I
  • karaviloside II