Abstract
T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Algorithms
-
Antigen-Antibody Complex / analysis
-
Antigen-Antibody Complex / immunology*
-
Binding Sites
-
Epitope Mapping / methods*
-
Epitopes, T-Lymphocyte / analysis
-
Epitopes, T-Lymphocyte / chemistry
-
Epitopes, T-Lymphocyte / immunology*
-
HLA Antigens / analysis
-
HLA Antigens / chemistry
-
HLA Antigens / immunology*
-
Peptides / analysis
-
Peptides / immunology*
-
Protein Binding
-
Protein Interaction Mapping / methods*
-
Sequence Analysis, Protein / methods*
Substances
-
Antigen-Antibody Complex
-
Epitopes, T-Lymphocyte
-
HLA Antigens
-
Peptides