Cytotoxic resveratrol oligomers from the tree bark of Dipterocarpus hasseltii

Muhtadi; Euis H Hakim; Lia D Juliawaty; Yana M Syah; Sjamsul A Achmad; Jalifah Latip; Emilio L Ghisalberti

doi:10.1016/j.fitote.2006.07.004

Cytotoxic resveratrol oligomers from the tree bark of Dipterocarpus hasseltii

Fitoterapia. 2006 Dec;77(7-8):550-5. doi: 10.1016/j.fitote.2006.07.004. Epub 2006 Sep 22.

Authors

Muhtadi¹, Euis H Hakim, Lia D Juliawaty, Yana M Syah, Sjamsul A Achmad, Jalifah Latip, Emilio L Ghisalberti

Affiliation

¹ Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

PMID: 17071016
DOI: 10.1016/j.fitote.2006.07.004

Abstract

A new resveratrol tetramer, named diptoindonesin E, was isolated from the acetone extract of the tree bark of Dipterocarpus hasseltii, together with five known resveratrol oligomers (-)-epsilon-viniferin, laevifonol, (-)-alpha-viniferin, vaticanol B, (-)-hopeaphenol, and a coumarin, scopoletin. The structures of these compounds were determined from spectroscopic evidence. Cytotoxicity test of the isolated compounds showed that hopeaphenol strongly inhibited murine leukemia P-388 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Agents, Phytogenic / therapeutic use
Cell Line, Tumor / drug effects
Ericales*
Mice
Phytotherapy*
Plant Bark
Plant Extracts / administration & dosage
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Resveratrol
Stilbenes / administration & dosage
Stilbenes / chemistry
Stilbenes / pharmacology*
Stilbenes / therapeutic use
Structure-Activity Relationship

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts
Stilbenes
diptoindonesin E
Resveratrol