Abstract
Type 2 diabetes is primarily associated with insulin resistance and beta-cell dysfunction. Maintenance of functional mature beta-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining beta-cell function. Defining the regulation of transcription factors as well as their regulation of important beta-cell genes like insulin will provide further insight into elucidating the mechanisms leading to beta-cell dysfunction.
MeSH terms
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Basic Helix-Loop-Helix Transcription Factors / physiology
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Eye Proteins / physiology
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Hepatocyte Nuclear Factor 1-alpha / physiology
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Hepatocyte Nuclear Factor 3-beta / physiology
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Homeodomain Proteins / physiology
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Humans
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Insulin-Secreting Cells / physiology*
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Maf Transcription Factors / physiology
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Nerve Tissue Proteins / physiology
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PAX6 Transcription Factor
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Paired Box Transcription Factors / physiology
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Pancreas / embryology
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Repressor Proteins / physiology
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Trans-Activators / physiology
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Transcription Factors / physiology*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Eye Proteins
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Hepatocyte Nuclear Factor 1-alpha
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Homeodomain Proteins
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Maf Transcription Factors
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Nerve Tissue Proteins
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PAX4 protein, human
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PAX6 Transcription Factor
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PAX6 protein, human
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Paired Box Transcription Factors
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Repressor Proteins
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Trans-Activators
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Transcription Factors
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pancreatic and duodenal homeobox 1 protein
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Hepatocyte Nuclear Factor 3-beta
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Neurogenic differentiation factor 1