In vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys alone and in combination with antimicrobial agents against multiresistant gram-positive cocci

Antimicrob Agents Chemother. 2007 Jan;51(1):354-8. doi: 10.1128/AAC.00344-06. Epub 2006 Oct 23.

Abstract

The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Multiple, Bacterial
  • Drug Synergism
  • Gram-Positive Cocci / classification
  • Gram-Positive Cocci / drug effects*
  • Hemolysis / drug effects
  • Humans
  • Lipoproteins / chemical synthesis
  • Lipoproteins / chemistry
  • Lipoproteins / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Peptides / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Lipoproteins
  • Peptides