Abstract
The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH(2) and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Multiple, Bacterial
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Drug Synergism
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Gram-Positive Cocci / classification
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Gram-Positive Cocci / drug effects*
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Hemolysis / drug effects
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Humans
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Lipoproteins / chemical synthesis
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Lipoproteins / chemistry
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Lipoproteins / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Peptides / chemical synthesis
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Peptides / chemistry
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Peptides / pharmacology*
Substances
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Anti-Bacterial Agents
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Lipoproteins
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Peptides