Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance

Antimicrob Agents Chemother. 2007 Jan;51(1):369-71. doi: 10.1128/AAC.00824-06. Epub 2006 Oct 23.

Abstract

Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.

MeSH terms

  • Alleles
  • Antifungal Agents / pharmacology
  • Candida / drug effects*
  • Candida / enzymology
  • Candida / genetics
  • Cloning, Molecular
  • Cytosine Deaminase / genetics
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • Drug Resistance, Fungal / genetics*
  • Fluconazole / pharmacology*
  • Flucytosine / pharmacology*
  • Fluorouracil / pharmacology*
  • Fungal Proteins / genetics
  • Genetic Complementation Test
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutation
  • Pentosyltransferases / genetics
  • Plasmids / genetics
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • DNA, Fungal
  • Fungal Proteins
  • Fluconazole
  • Flucytosine
  • Pentosyltransferases
  • uracil phosphoribosyltransferase
  • Cytosine Deaminase
  • Fluorouracil

Associated data

  • GENBANK/DQ372917
  • GENBANK/DQ372926