Abstract
Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.
MeSH terms
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Alleles
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Antifungal Agents / pharmacology
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Candida / drug effects*
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Candida / enzymology
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Candida / genetics
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Cloning, Molecular
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Cytosine Deaminase / genetics
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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Drug Resistance, Fungal / genetics*
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Fluconazole / pharmacology*
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Flucytosine / pharmacology*
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Fluorouracil / pharmacology*
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Fungal Proteins / genetics
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Genetic Complementation Test
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Pentosyltransferases / genetics
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Plasmids / genetics
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Sequence Analysis, DNA
Substances
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Antifungal Agents
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DNA, Fungal
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Fungal Proteins
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Fluconazole
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Flucytosine
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Pentosyltransferases
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uracil phosphoribosyltransferase
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Cytosine Deaminase
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Fluorouracil
Associated data
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GENBANK/DQ372917
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GENBANK/DQ372926