The aim of the present study was to examine the potential of hydrostatic extrusion for the fabrication of high-strength materials for medical applications. The materials examined were 316LVM steel and technically pure titanium. The microstructures and mechanical properties of the materials before and after hydrostatic extrusion were analysed. It was found that the hydrostatic extrusion process resulted in a substantial refinement of the material microstructures. The refinement of the microstructure was accompanied by an improvement of the mechanical properties, such as the microhardness and yield stress.