Abstract
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Binding Sites
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Gene Expression Regulation*
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Humans
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Ligands
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Models, Biological
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Neoplasms / enzymology*
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Neoplasms / etiology
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Oxidation-Reduction
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Protein Tyrosine Phosphatases / classification
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Protein Tyrosine Phosphatases / genetics*
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Protein Tyrosine Phosphatases / physiology
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Signal Transduction*
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Structure-Activity Relationship
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Tumor Suppressor Proteins / genetics
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Tumor Suppressor Proteins / physiology*
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Tyrosine / metabolism
Substances
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Ligands
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Tumor Suppressor Proteins
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Tyrosine
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Protein Tyrosine Phosphatases