Results of surgical treatment of patients with cardiac valves prosthetic endocarditis are discussed. General hospital lethality was 15.4%. Immediate results of operations using different type of prosthetic cardiac valves were analyzed. Biological grafts permits to decrease the rate of prosthetic endocarditic recurrence on hospital stage. Urgency of repeated surgery and also radical resection of infected focus with possible reconstruction of fibrous ring integrity influence hospital lethality.