Promiscuous interactions between AMPA-Rs and MAGUKs

Stephen M Fitzjohn; Andrew J Doherty; Graham L Collingridge

doi:10.1016/j.neuron.2006.10.002

Promiscuous interactions between AMPA-Rs and MAGUKs

Neuron. 2006 Oct 19;52(2):222-4. doi: 10.1016/j.neuron.2006.10.002.

Authors

Stephen M Fitzjohn¹, Andrew J Doherty, Graham L Collingridge

Affiliation

¹ MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom.

PMID: 17046684
DOI: 10.1016/j.neuron.2006.10.002

Abstract

What controls the number of AMPA receptors at excitatory synapses? MAGUKs are known to play a critical role in this process, but which ones are involved and when has been contentious. In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons.

Publication types

Review
Comment

MeSH terms

Animals
Disks Large Homolog 4 Protein
Down-Regulation / physiology
Guanylate Kinases
Hippocampus / metabolism*
Hippocampus / ultrastructure
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism*
Membrane Proteins / genetics
Membrane Proteins / metabolism*
Neuropeptides / genetics
Neuropeptides / metabolism
Protein Transport / physiology
Receptors, AMPA / metabolism*
Synapses / metabolism*
Synapses / ultrastructure
Synaptic Transmission / physiology*

Substances

Disks Large Homolog 4 Protein
Dlg4 protein, mouse
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Mpp2 protein, rat
Neuropeptides
Receptors, AMPA
Dlgh3 protein, mouse
Guanylate Kinases