Abstract
An initiative was taken to determine the in vitro activity of daptomycin against 85 Gram-positive isolates with reduced susceptibilities to linezolid and quinupristin/dalfopristin. Daptomycin had potent activity against all strains, with a Staphylococcus spp. minimum inhibitory concentration (MIC) < or =2 microg/mL and an Enterococcus spp. MIC < or =8 microg/mL. Resistance to linezolid and quinupristin/dalfopristin appears to be independent of reduced susceptibility to daptomycin.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology
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Daptomycin / pharmacology*
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Drug Resistance, Bacterial
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Enterococcus faecalis / drug effects
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Enterococcus faecium / drug effects
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Gram-Positive Bacteria / drug effects*
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Humans
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Linezolid
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Oxazolidinones / pharmacology*
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Staphylococcus aureus / drug effects
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Virginiamycin / pharmacology*
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Virginiamycin
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quinupristin-dalfopristin
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Linezolid
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Daptomycin