Right bundle branch block and long-term mortality in patients with acute congestive heart failure

J Intern Med. 2006 Nov;260(5):421-8. doi: 10.1111/j.1365-2796.2006.01703.x.

Abstract

Objectives: Risk stratification in acute congestive heart failure (ACHF) is poorly defined. The aim of the present study was to assess the impact of right bundle brunch block (RBBB) on long-term mortality in patients presenting with ACHF.

Methods and results: The initial 12-lead electrocardiogram was analysed for RBBB in 192 consecutive patients presenting with ACHF to the emergency department. The primary endpoint was all-cause mortality during 720-day follow-up. This study included an elderly cohort (mean age 74 years) of ACHF patients. RBBB was present in 27 patients (14%). Age, sex, B-type natriuretic peptide levels and initial management were similar in patients with RBBB when compared with patients without RBBB. However, patients with RBBB more often had pulmonary comorbidity. A total of 84 patients died during follow-up. Kaplan-Meier analysis revealed that mortality at 720 days was significantly higher in patients with RBBB when compared with patients without RBBB (63% vs. 39%, P = 0.004). In Cox proportional hazard analysis, RBBB was associated with a two-fold increase in mortality (hazard ratio 2.18, 95% CI 1.26-3.66; P = 0.003). This association persisted after adjustment for age and comorbidity.

Conclusions: RBBB is a powerful predictor of mortality in patients with ACHF. Early identification of this high-risk group may help to offer tailored treatment in order to improve outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bundle-Branch Block / epidemiology*
  • Comorbidity
  • Electrocardiography / instrumentation
  • Female
  • Heart Failure / mortality*
  • Humans
  • Hypertension / epidemiology
  • Male
  • Proportional Hazards Models
  • Prospective Studies
  • Pulmonary Artery
  • Switzerland / epidemiology
  • Ventricular Dysfunction, Right / epidemiology*