Synthesis of diverse analogues of Oenostacin and their antibacterial activities

Bioorg Med Chem. 2007 Jan 1;15(1):518-25. doi: 10.1016/j.bmc.2006.09.034. Epub 2006 Oct 10.

Abstract

Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC(50) ranging from 0.49 to 0.67 microM as compared to Oenostacin (EC(50)=0.12 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Combinatorial Chemistry Techniques / methods
  • Dose-Response Relationship, Drug
  • Hydroxybenzoates / chemical synthesis*
  • Hydroxybenzoates / chemistry
  • Hydroxybenzoates / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Staphylococcus aureus / drug effects*
  • Staphylococcus epidermidis / drug effects*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Hydroxybenzoates
  • oenostacin