A projection of the impact of lipid-lowering therapy on high-risk employee disability and medical costs

J Occup Environ Med. 2006 Oct;48(10):1014-22. doi: 10.1097/01.jom.0000237773.26755.78.

Abstract

Objective: The objective of this study was to examine the impact of introducing rosuvastatin calcium on direct and indirect costs among patients at high risk for coronary heart disease.

Methods: An economic simulation model was developed to project the number of cardiovascular events and associated direct and indirect costs under varying treatment scenarios.

Results: In an average-sized commercial health plan with 210,000 covered lives and 9,336 high-risk patients, an uptake of rosuvastatin by 11% of high-risk patients would result in eight fewer cardiovascular events, a net savings of 0.85 million dollars in direct medical costs and a net savings of 36,404 dollars in productivity loss over a period of 5 years. The overall reduction in total costs is equivalent to 1735 dollars per rosuvastatin-treated patient.

Conclusions: At current statin prices, the use of rosuvastatin could lead to fewer cardiovascular events and lower direct and indirect costs.

Publication types

  • Evaluation Study

MeSH terms

  • Cardiovascular Diseases / economics*
  • Cardiovascular Diseases / prevention & control*
  • Cost Savings
  • Cost-Benefit Analysis
  • Fluorobenzenes / administration & dosage*
  • Fluorobenzenes / economics
  • Forecasting
  • Health Care Costs / statistics & numerical data*
  • Humans
  • Hypolipidemic Agents / administration & dosage*
  • Hypolipidemic Agents / economics
  • Insurance, Major Medical / economics
  • Markov Chains
  • Models, Econometric
  • Pyrimidines / administration & dosage*
  • Pyrimidines / economics
  • Rosuvastatin Calcium
  • Sick Leave / economics
  • Sick Leave / trends*
  • Sulfonamides / administration & dosage*
  • Sulfonamides / economics

Substances

  • Fluorobenzenes
  • Hypolipidemic Agents
  • Pyrimidines
  • Sulfonamides
  • Rosuvastatin Calcium