Abstract
Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caffeic Acids / analysis
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Caffeic Acids / pharmacology
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Central Nervous System Stimulants / metabolism
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Central Nervous System Stimulants / pharmacology
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Chlorogenic Acid / metabolism*
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Chlorogenic Acid / pharmacology*
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Chlorogenic Acid / urine
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Chromatography, High Pressure Liquid
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Coumaric Acids / analysis
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Coumaric Acids / pharmacology
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Feces
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Flavonoids
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Male
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Mice
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Mice, Inbred Strains
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Motor Activity / drug effects*
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Phenols
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Polyphenols
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Rats
Substances
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Caffeic Acids
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Central Nervous System Stimulants
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Coumaric Acids
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Flavonoids
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Phenols
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Polyphenols
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Chlorogenic Acid
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caffeic acid