Layer guided-acoustic plate mode biosensors for monitoring MHC-peptide interactions

Analyst. 2006 Aug;131(8):892-4. doi: 10.1039/b604812a. Epub 2006 Jun 28.

Abstract

The transduction signals from the immobilisation of a class I heavy chain, HLA-A2, on a layer guided acoustic plate mode device, followed by binding of beta(2)-microglobulin and subsequent selective binding of a target peptide are reported.

MeSH terms

  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • HLA-A2 Antigen / metabolism*
  • Humans
  • Microscopy, Acoustic
  • Protein Folding
  • Protein Interaction Mapping
  • Streptavidin / metabolism*
  • beta 2-Microglobulin / metabolism

Substances

  • HLA-A2 Antigen
  • beta 2-Microglobulin
  • Streptavidin