In submicron superconducting squares in a homogeneous magnetic field, Ginzburg-Landau theory may admit solutions of the vortex-antivortex type, conforming to the symmetry of the sample [L. F. Chibotaru, Nature (London) 408, 833 (2000)10.1038/35048521]. Here we show that these fascinating, but never experimentally observed states, can be enforced by artificial fourfold pinning, with their diagnostic features enhanced by orders of magnitude. The second-order nucleation of vortex-antivortex molecules can be driven by either temperature or an applied magnetic field, with stable asymmetric vortex-antivortex equilibria found on its path.