The significance of peroxisomes in methanol metabolism in methylotrophic yeast

Ida J van der Klei; Hiroya Yurimoto; Yasuyoshi Sakai; Marten Veenhuis

doi:10.1016/j.bbamcr.2006.07.016

The significance of peroxisomes in methanol metabolism in methylotrophic yeast

Biochim Biophys Acta. 2006 Dec;1763(12):1453-62. doi: 10.1016/j.bbamcr.2006.07.016. Epub 2006 Sep 1.

Authors

Ida J van der Klei¹, Hiroya Yurimoto, Yasuyoshi Sakai, Marten Veenhuis

Affiliation

¹ Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, P.O. Box 14, NL-9750 AA Haren, The Netherlands.

PMID: 17023065
DOI: 10.1016/j.bbamcr.2006.07.016

Abstract

The capacity to use methanol as sole source of carbon and energy is restricted to relatively few yeast species. This may be related to the low efficiency of methanol metabolism in yeast, relative to that of prokaryotes. This contribution describes the details of methanol metabolism in yeast and focuses on the significance of compartmentalization of this metabolic pathway in peroxisomes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alcohol Oxidoreductases / metabolism
Aldehyde-Ketone Transferases / metabolism
Catalase / metabolism
Formaldehyde / metabolism
Gene Expression Regulation, Fungal
Glutathione Peroxidase / metabolism
Methanol / metabolism*
Peroxisomes / enzymology*
Pichia / genetics
Pichia / metabolism*
Thiolester Hydrolases / metabolism

Substances

Formaldehyde
Alcohol Oxidoreductases
alcohol oxidase
Catalase
Glutathione Peroxidase
Aldehyde-Ketone Transferases
formaldehyde transketolase
Thiolester Hydrolases
s-formylglutathione hydrolase
Methanol