Abstract
A series of new acetylenic thioquinolines containing propargyl, 2-butynyl, or 4-bromo-2-butynyl groups has been prepared and tested for antiproliferative activity in vitro against the cells of human [SW707 (colon cancer), CCRF/CEM (leukemia)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. All the compounds obtained exhibited antiproliferative activity. The most active compounds 4h and 41-m have ID50 values ranging from 0.2 to 3.6 microg/ml, comparable to that of the reference compound cisplatin.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cisplatin / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mice
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Quinolines / chemical synthesis*
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Quinolines / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Tetrazolium Salts
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Thiazoles
Substances
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Antineoplastic Agents
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Indicators and Reagents
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Quinolines
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Tetrazolium Salts
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Thiazoles
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thiazolyl blue
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Cisplatin