Abstract
Large noncoding RNAs (lncRNAs) have emerged as key players in regulating various fundamental cellular processes. Recent reports identify a functional lncRNA, Evf-2, that operates during development to control the expression of specific homeodomain proteins, and they provide important insights into the mechanism of cooperation between a newly discovered nuclear receptor co-repressor protein (SLIRP) and steroid receptor activator RNA. Evf-2 is the first example of lncRNA directly involved in organogenesis in vertebrates.
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / physiology
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Alternative Splicing
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Amino Acid Motifs
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Animals
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Cell Line, Tumor
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Enhancer Elements, Genetic
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Gene Expression Regulation / genetics
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Gene Expression Regulation / physiology*
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Genes, Reporter
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Histone Acetyltransferases / genetics
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Histone Acetyltransferases / physiology
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Homeodomain Proteins / genetics
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Homeodomain Proteins / physiology
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Humans
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Mice
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Nuclear Receptor Coactivator 1
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Nucleic Acid Conformation
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Promoter Regions, Genetic
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RNA / genetics
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RNA / physiology*
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RNA, Small Interfering / pharmacology
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RNA-Binding Proteins / physiology
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Cytoplasmic and Nuclear / physiology
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Repressor Proteins / genetics
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Repressor Proteins / physiology
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Transcription Factors / genetics
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Transcription Factors / physiology
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Transcription, Genetic / physiology*
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Transfection
Substances
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Adaptor Proteins, Signal Transducing
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Homeodomain Proteins
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RNA, Small Interfering
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RNA-Binding Proteins
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Receptors, Cytoplasmic and Nuclear
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Repressor Proteins
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SLIRP protein, human
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SPHKAP protein, human
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Transcription Factors
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RNA
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Histone Acetyltransferases
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NCOA1 protein, human
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Ncoa1 protein, mouse
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Nuclear Receptor Coactivator 1