Neuron firing in driven nonlinear integrate-and-fire models

Math Biosci. 2007 Jun;207(2):302-11. doi: 10.1016/j.mbs.2006.08.014. Epub 2006 Aug 25.

Abstract

Statistical properties of neuron firing are studied in the framework of a nonlinear leaky integrate-and-fire model that is driven by a slow periodic subthreshold signal. The firing events are characterized by first passage time densities. The experimentally better accessible interspike interval density generally depends on the sojourn times in a refractory state of the neuron. This aspect is not part of the integrate-and-fire model and must be modelled additionally. For a large class of refractory dynamics, a general expression for the interspike interval density is given and further evaluated for the two cases with an instantaneous resetting (i.e. no refractory state) and a refractory state possessing a deterministic lifetime. First passage time densities and interspike interval densities following from the proposed theory compare favorably with precise numerical simulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Algorithms
  • Animals
  • Computer Simulation
  • Electric Capacitance
  • Electrophysiology
  • Humans
  • Markov Chains
  • Models, Neurological*
  • Neural Conduction / physiology*
  • Neurons / physiology
  • Nonlinear Dynamics*
  • Refractory Period, Electrophysiological / physiology