Cisplatin-based chemotherapy is one of the most common chemotherapy regimens that is complicated by thromboembolic events. A wide spectrum of vascular events exists, including venous and arterial thromboses of varying severity and location. However, total occlusion of the aorta is very unusual. We describe two patients with atherosclerotic vascular disease who developed occlusion of the abdominal aorta after cisplatin-based chemotherapy.