Abstract
Native valve fungal endocarditis is an uncommon disease with a high mortality rate. We present the clinical features, histological findings and outcome of 2 patients with native valve Aspergillus endocarditis. Both patients had aplastic anaemia as a predisposing disease. The diagnosis was made by Duke's criteria in 1 case and by histology in the other. Surgery was precluded owing to profound thrombocytopenia. Both patients had fatal outcome despite administration of liposomal amphotericin beta.
MeSH terms
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Adolescent
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Adult
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Amphotericin B / therapeutic use
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Anemia, Aplastic / complications*
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Antifungal Agents / therapeutic use
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Aspergillosis / diagnosis*
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Aspergillosis / drug therapy
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Aspergillosis / etiology*
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Caspofungin
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Echinocandins
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Endocarditis / drug therapy
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Endocarditis / etiology*
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Endocarditis / microbiology*
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Fatal Outcome
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Female
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Humans
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Itraconazole / therapeutic use
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Lipopeptides
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Male
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Peptides, Cyclic / therapeutic use
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides, Cyclic
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liposomal amphotericin B
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Itraconazole
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Amphotericin B
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Caspofungin