Abstract
Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / therapeutic use
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Animals
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Antifungal Agents / therapeutic use
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Aspergillosis* / drug therapy
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Aspergillosis* / microbiology
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Aspergillosis* / mortality
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Aspergillus fumigatus / isolation & purification
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Aspergillus fumigatus / pathogenicity*
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Disease Models, Animal*
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Humans
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Liposomes
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Lung / microbiology
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Lung Diseases, Fungal* / drug therapy
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Lung Diseases, Fungal* / microbiology
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Lung Diseases, Fungal* / mortality
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Mice
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Reproducibility of Results
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Treatment Outcome
Substances
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Antifungal Agents
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Liposomes
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liposomal amphotericin B
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Amphotericin B