Integrons containing the VIM-2 metallo-beta-lactamase gene among imipenem-resistant Pseudomonas aeruginosa strains from different Chinese hospitals

Yun-Song Yu; Ting-Ting Qu; Jian-Ying Zhou; Jie Wang; Hong-Yang Li; Timothy R Walsh

doi:10.1128/JCM.01558-06

Integrons containing the VIM-2 metallo-beta-lactamase gene among imipenem-resistant Pseudomonas aeruginosa strains from different Chinese hospitals

J Clin Microbiol. 2006 Nov;44(11):4242-5. doi: 10.1128/JCM.01558-06. Epub 2006 Sep 27.

Authors

Yun-Song Yu¹, Ting-Ting Qu, Jian-Ying Zhou, Jie Wang, Hong-Yang Li, Timothy R Walsh

Affiliation

¹ Infectious Disease Department, The 1st Affiliated Hospital, Medical School, Zhejiang University, The Key Laboratory of the Infectious Diseases of Public Health Ministry, Hangzhou, Zhejiang, China.

Abstract

A total of 140 nonrepetitive strains of imipenem-resistant Pseudomonas aeruginosa were isolated from five different Chinese hospitals. Fourteen isolates were confirmed to contain the VIM-2 metallo-beta-lactamase gene. Twelve isolates harbored two kinds of class 1 integron, containing both VIM-2- and aminoglycoside-resistant genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Conjugation, Genetic
DNA Transposable Elements
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Imipenem / pharmacology*
Integrons*
Polymerase Chain Reaction
Pseudomonas aeruginosa / drug effects
Pseudomonas aeruginosa / enzymology
Pseudomonas aeruginosa / genetics*
beta-Lactamases / genetics*

Substances

DNA Transposable Elements
Imipenem
beta-lactamase bla(vim-2)
beta-Lactamases