Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa

Neurology. 2006 Sep 26;67(6):1053-5. doi: 10.1212/01.wnl.0000239154.51331.c4.

Abstract

We report myocardial injury in 20 recombinant factor VIIa (rFVIIa) treated and 110 nontreated patients with intracerebral hemorrhage. Patients were treated or received standard medical management. All received EKG and cardiac enzyme testing. Elevated troponin occurred in 20% treated vs 3% nontreated (p = 0.02). Myocardial infarction occurred in 10% vs 1% (p = 0.01). We found a significant increase in myocardial injury in rFVIIa treated patients.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Cerebral Hemorrhage / drug therapy*
  • Cerebral Hemorrhage / mortality
  • Electrocardiography / methods
  • Factor VII / adverse effects*
  • Factor VIIa
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / chemically induced*
  • Recombinant Proteins / adverse effects
  • Time Factors
  • Troponin / metabolism

Substances

  • Recombinant Proteins
  • Troponin
  • Factor VII
  • recombinant FVIIa
  • Factor VIIa