Abstract
The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2'-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Bromine / chemistry*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Phenols / chemical synthesis
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Phenols / chemistry
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Phenols / pharmacology*
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Pyrroles / chemical synthesis
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Pyrroles / chemistry*
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Pyrroles / pharmacology
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Spectroscopy, Fourier Transform Infrared
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Phenols
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Pyrroles
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monodeoxypyoluteorin
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Bromine