Abstract
The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetogenins
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Drug Screening Assays, Antitumor
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Fatty Alcohols* / chemistry
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Fatty Alcohols* / isolation & purification
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Fatty Alcohols* / pharmacology
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Humans
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KB Cells
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Lactones* / chemistry
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Lactones* / isolation & purification
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Lactones* / pharmacology
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Molecular Structure
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Tumor Cells, Cultured
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Vietnam
Substances
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Acetogenins
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Antineoplastic Agents, Phytogenic
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Fatty Alcohols
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Furans
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Lactones
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plagionicin A