Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum

J Nat Prod. 2006 Sep;69(9):1289-94. doi: 10.1021/np060168j.

Abstract

The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetogenins
  • Annonaceae / chemistry*
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Drug Screening Assays, Antitumor
  • Fatty Alcohols* / chemistry
  • Fatty Alcohols* / isolation & purification
  • Fatty Alcohols* / pharmacology
  • Furans / chemistry
  • Furans / isolation & purification*
  • Furans / pharmacology
  • Humans
  • KB Cells
  • Lactones* / chemistry
  • Lactones* / isolation & purification
  • Lactones* / pharmacology
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Tumor Cells, Cultured
  • Vietnam

Substances

  • Acetogenins
  • Antineoplastic Agents, Phytogenic
  • Fatty Alcohols
  • Furans
  • Lactones
  • plagionicin A