(-)-Agelasidine A from Agelas clathrodes

Z Naturforsch C J Biosci. 2006 Jul-Aug;61(7-8):472-6. doi: 10.1515/znc-2006-7-802.

Abstract

(-)-Agelasidine A was identified from the methanol extract of the marine sponge Agelas clathrodes for the first time together with zooanemonin, 1-carboxymethylnicotinic acid, hymenidin, mukanadins A and C, monobromodispacamide, agelasidine D, 2-amide-4-bromopyrrole, O-methyltryptophan and an agelasines mixture. The structures were characterized by spectroscopic methods. (-)-Agelasidine A was tested for antibacterial and antifungal activities and shown to act as a bacteriostatic agent as it inhibited the growth of Staphylococcus aureus and partially the growth of other bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agelas / chemistry*
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Guanidines / chemistry
  • Guanidines / isolation & purification*
  • Guanidines / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Staphylococcus / drug effects
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / growth & development
  • Sulfones / chemistry
  • Sulfones / isolation & purification*
  • Sulfones / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Guanidines
  • Sulfones
  • agelasidine A