Abstract
(-)-Agelasidine A was identified from the methanol extract of the marine sponge Agelas clathrodes for the first time together with zooanemonin, 1-carboxymethylnicotinic acid, hymenidin, mukanadins A and C, monobromodispacamide, agelasidine D, 2-amide-4-bromopyrrole, O-methyltryptophan and an agelasines mixture. The structures were characterized by spectroscopic methods. (-)-Agelasidine A was tested for antibacterial and antifungal activities and shown to act as a bacteriostatic agent as it inhibited the growth of Staphylococcus aureus and partially the growth of other bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agelas / chemistry*
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Guanidines / chemistry
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Guanidines / isolation & purification*
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Guanidines / pharmacology*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Staphylococcus / drug effects
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
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Sulfones / chemistry
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Sulfones / isolation & purification*
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Sulfones / pharmacology*
Substances
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Anti-Bacterial Agents
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Guanidines
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Sulfones
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agelasidine A