Abstract
The population pharmacokinetics of desmopressin in children with nocturnal enuresis and in healthy adults were compared using a 1-compartment model with first-order absorption and first-order elimination. In addition, the model consisted of a number of transit compartments before absorption to describe a lag-time. The model gave an adequate description of adult as well as children data and provided a statistically significant better fit to data than a standard lag-time model. The main difference in the pharmacokinetics between children and adults was the absorption delay. The pharmacokinetic difference was minor and presumably of no clinical relevance.
Publication types
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Administration, Sublingual
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Adolescent
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Adult
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Age Factors
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Algorithms
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Antidiuretic Agents / administration & dosage
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Antidiuretic Agents / pharmacokinetics*
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Antidiuretic Agents / therapeutic use
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Biological Availability
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Child
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Cross-Over Studies
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Deamino Arginine Vasopressin / administration & dosage
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Deamino Arginine Vasopressin / pharmacokinetics*
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Deamino Arginine Vasopressin / therapeutic use
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Dosage Forms
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Dose-Response Relationship, Drug
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Double-Blind Method
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Freeze Drying
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Humans
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Intestinal Absorption
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Metabolic Clearance Rate
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Middle Aged
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Models, Biological
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Nocturnal Enuresis / drug therapy*
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Nocturnal Enuresis / metabolism
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Tissue Distribution
Substances
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Antidiuretic Agents
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Dosage Forms
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Deamino Arginine Vasopressin