Hydroxyl radicals scavenging activity of N-substituted chitosan and quaternized chitosan

Zhanyong Guo; Hongying Liu; Xiaolin Chen; Xia Ji; Pengcheng Li

doi:10.1016/j.bmcl.2006.09.009

Hydroxyl radicals scavenging activity of N-substituted chitosan and quaternized chitosan

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6348-50. doi: 10.1016/j.bmcl.2006.09.009. Epub 2006 Sep 20.

Authors

Zhanyong Guo¹, Hongying Liu, Xiaolin Chen, Xia Ji, Pengcheng Li

Affiliation

¹ Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

PMID: 16987660
DOI: 10.1016/j.bmcl.2006.09.009

Abstract

N-substituted chitosan and quaternized chitosan were synthesized and their antioxidant activity against hydroxyl radicals was assessed, respectively. Compared with the antioxidant activity of chitosan, the results indicated that the two kinds of chitosan derivatives had different scavenging ability on hydroxyl radicals, which should be related to the form of amido in the two kinds of chitosan derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / chemical synthesis
Antioxidants / pharmacology
Carbohydrate Conformation
Chitosan / analogs & derivatives*
Chitosan / chemistry
Chitosan / pharmacology*
Free Radical Scavengers / chemical synthesis
Free Radical Scavengers / chemistry
Free Radical Scavengers / pharmacology
Spectrophotometry, Infrared

Substances

Antioxidants
Free Radical Scavengers
Chitosan