Analgesic effect of corticotropin-releasing hormone: involvement of the hypothalamic-pituitary-adrenocortical axis into its realization

A I Bogdanov; N I Yarushkina

doi:10.1007/s10517-006-0123-2

Analgesic effect of corticotropin-releasing hormone: involvement of the hypothalamic-pituitary-adrenocortical axis into its realization

Bull Exp Biol Med. 2006 Feb;141(2):184-6. doi: 10.1007/s10517-006-0123-2.

Authors

A I Bogdanov¹, N I Yarushkina

Affiliation

¹ Laboratory of Experimental Endocrinology, I P Pavlov Institute of Physiology, Russian Academy of Sciences, St Petersburg.

PMID: 16984092
DOI: 10.1007/s10517-006-0123-2

Abstract

Involvement of hypothalamic-pituitary-adrenocortical axis into the analgesic effect of corticotropin-releasing hormone after its systemic administration was studied in experiments on rats. Pharmacological blockade of the hypothalamic-pituitary-adrenocortical axis decreased the duration and degree of the analgesic effect of corticotropin-releasing hormone. This analgesic effect can be mediated via two pathways: related to hormones of the hypothalamic-pituitary-adrenocortical axis and independent of these hormones.

MeSH terms

Analgesics, Non-Narcotic / pharmacology*
Animals
Corticotropin-Releasing Hormone / pharmacology*
Hydrocortisone / pharmacology
Hypothalamo-Hypophyseal System / drug effects*
Hypothalamo-Hypophyseal System / physiology
Male
Nociceptors / drug effects
Nociceptors / physiology
Pain Measurement
Pain Threshold / drug effects
Pain Threshold / physiology
Pituitary-Adrenal System / drug effects*
Pituitary-Adrenal System / physiology
Rats
Rats, Sprague-Dawley

Substances

Analgesics, Non-Narcotic
Corticotropin-Releasing Hormone
Hydrocortisone