Abstract
Among 10 subjects colonized with Escherichia coli isolates with reduced susceptibility to fluoroquinolones, the median duration of colonization following hospital discharge was 80 days (range, 8 to 172 days). Colonization was longer for isolates demonstrating organic-solvent tolerance than for isolates that were not organic-solvent tolerant (151 versus 29 days, respectively; P = 0.07) but was not associated with other resistance mechanisms, demographics, or antibiotic use.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli Infections / microbiology*
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Feces / microbiology*
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Female
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Fluoroquinolones / pharmacology*
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Follow-Up Studies
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Humans
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Longitudinal Studies
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Patient Discharge
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Telephone
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Time Factors
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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DNA Topoisomerase IV
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DNA Gyrase