Duration of outpatient fecal colonization due to Escherichia coli Isolates with decreased susceptibility to fluoroquinolones: longitudinal study of patients recently discharged from the hospital

Antimicrob Agents Chemother. 2006 Nov;50(11):3939-43. doi: 10.1128/AAC.00503-06. Epub 2006 Sep 18.

Abstract

Among 10 subjects colonized with Escherichia coli isolates with reduced susceptibility to fluoroquinolones, the median duration of colonization following hospital discharge was 80 days (range, 8 to 172 days). Colonization was longer for isolates demonstrating organic-solvent tolerance than for isolates that were not organic-solvent tolerant (151 versus 29 days, respectively; P = 0.07) but was not associated with other resistance mechanisms, demographics, or antibiotic use.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / genetics
  • Drug Resistance, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli Infections / microbiology*
  • Feces / microbiology*
  • Female
  • Fluoroquinolones / pharmacology*
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Patient Discharge
  • Telephone
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • DNA Topoisomerase IV
  • DNA Gyrase