Abstract
Carriers of BRCA2 germline mutation have a significantly increased lifetime risk of breast and ovarian cancer compared to non carriers. Several other carcinomas seem to be associated with BRCA2 mutations: pancreas, prostate, larynx, gallbladder, bile duct cancer, and malignant melanoma. We described a case of a 67-year-old BRCA2 mutation carrier of Caucasian, non-Jewish, ethnic origin who successively developed 4 primary malignancies in 30 months: breast ductal carcinoma, chronic lymphatic leukemia, ovarian serous papillary carcinoma, and endocervical adenocarcinoma. This is the first case of 4 primary malignancies in a BRCA mutation carrier, also occurred in such a short observation period. Chronic lymphatic leukemia and endocervical adenocarcinoma have not been yet associated to BRCA2 germline mutation.
MeSH terms
-
Adenocarcinoma / genetics
-
Adenocarcinoma / pathology
-
Adenocarcinoma / therapy
-
Adult
-
Aged
-
BRCA2 Protein / genetics*
-
Breast Neoplasms / genetics*
-
Breast Neoplasms / pathology
-
Breast Neoplasms / therapy
-
Carcinoma, Ductal, Breast / genetics
-
Carcinoma, Ductal, Breast / pathology
-
Carcinoma, Ductal, Breast / therapy
-
Cystadenocarcinoma, Papillary / genetics
-
Cystadenocarcinoma, Papillary / pathology
-
Cystadenocarcinoma, Papillary / therapy
-
Cystadenocarcinoma, Serous / genetics
-
Cystadenocarcinoma, Serous / pathology
-
Cystadenocarcinoma, Serous / therapy
-
Female
-
Genetic Predisposition to Disease
-
Germ-Line Mutation*
-
Humans
-
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
-
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
-
Leukemia, Lymphocytic, Chronic, B-Cell / therapy
-
Male
-
Middle Aged
-
Neoplasms, Multiple Primary / genetics*
-
Neoplasms, Multiple Primary / pathology
-
Neoplasms, Multiple Primary / therapy
-
Ovarian Neoplasms / genetics*
-
Ovarian Neoplasms / pathology
-
Ovarian Neoplasms / therapy
-
Pedigree
-
Uterine Cervical Neoplasms / genetics*
-
Uterine Cervical Neoplasms / pathology
-
Uterine Cervical Neoplasms / therapy