Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro

Yi-Chen Chia; Fang-Rong Chang; Chin-Chung Wu; Che-Ming Teng; Keh-Shaw Chen; Yang-Chang Wu

doi:10.1055/s-2006-947196

Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro

Planta Med. 2006 Oct;72(13):1238-41. doi: 10.1055/s-2006-947196. Epub 2006 Sep 18.

Authors

Yi-Chen Chia¹, Fang-Rong Chang, Chin-Chung Wu, Che-Ming Teng, Keh-Shaw Chen, Yang-Chang Wu

Affiliation

¹ Department of Food Science & Technology, Tajen Institute of Technology, Ping Tung Hsien, Taiwan.

PMID: 16981134
DOI: 10.1055/s-2006-947196

Abstract

Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Blood Platelets / drug effects
Cells, Cultured
Isoquinolines / chemistry
Isoquinolines / isolation & purification
Isoquinolines / pharmacology*
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plants / chemistry
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / isolation & purification
Platelet Aggregation Inhibitors / pharmacology*
Rabbits

Substances

Alkaloids
Isoquinolines
Plant Extracts
Platelet Aggregation Inhibitors