Autoantibody specific for a thyroglobulin epitope inducing experimental autoimmune thyroiditis or its anti-idiotype correlates with the disease

Eur J Immunol. 1990 Jul;20(7):1535-9. doi: 10.1002/eji.1830200719.

Abstract

In order to elucidate the role of anti-thyroglobulin (Tg) autoantibodies (A-Ab) in experimental autoimmune thyroiditis (EAT), a kinetic study was conducted in EAT-susceptible (CBA/J) and non-susceptible (C57BL/6) strains of mice. From day 0 to 70 post-Tg immunization, titers of A-Ab to Tg and to the linear 5-10-kDa Tg tryptic fragment inducing EAT as well as anti-idiotypic A-Ab representing the internal image of the thyroidogeneic antigen were measured. EAT onset, development and recovery correlate with the presence of two subsets of A-Ab only in susceptible strains of mice. First, with the presence of anti-Tg A-Ab to one determinant borne by the linear 5-10-kDa Tg tryptic fragment, and second with the presence of anti-idiotypic A-Ab specific for the monoclonal anti-Tg A-Ab (3B8G9) paratope which binds to Tg determinant inducing EAT.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Anti-Idiotypic / immunology
  • Autoantibodies / analysis*
  • Disease Models, Animal
  • Disease Susceptibility / immunology
  • Epitopes / immunology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Peptide Fragments / immunology
  • Thyroglobulin / immunology*
  • Thyroiditis, Autoimmune / immunology*

Substances

  • Antibodies, Anti-Idiotypic
  • Autoantibodies
  • Epitopes
  • Peptide Fragments
  • Thyroglobulin