This paper reports on an attempt to use CD and CD/PHB ICs as nucleation agents for PHB in a high-speed melt spinning process. At first rheological and thermal properties of the nucleated melts are determined in order to assess the influence of the nucleating agents. Then spinning tests are carried out. Thermal and textile properties of the spun PHB fibers are also determined. An estimation of the improvement of inhibition of the secondary crystallization from use of the described blood compatible nucleating agents is given.