Therapeutic tricyclic antidepressant drug monitoring in younger and older depressive patients

Pharmacol Rep. 2006 Jul-Aug;58(4):501-6.

Abstract

The present study shows the evaluation of clinical state and serum level of tricyclic antidepressants in thirty-eight depressive younger and elderly patients during 8-week observation. We observed no statistically significant differences, neither in psychometric scale scores nor in drug serum levels in both groups of patients.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aging*
  • Antidepressive Agents, Tricyclic / adverse effects
  • Antidepressive Agents, Tricyclic / blood
  • Antidepressive Agents, Tricyclic / pharmacokinetics
  • Antidepressive Agents, Tricyclic / therapeutic use*
  • Clomipramine / therapeutic use
  • Depression / blood
  • Depression / drug therapy*
  • Drug Monitoring*
  • Female
  • Humans
  • Imipramine / therapeutic use
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Time Factors
  • Treatment Outcome

Substances

  • Antidepressive Agents, Tricyclic
  • Clomipramine
  • Imipramine