Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles

Tsung-Hsien Lee; Ming-Yih Wu; Hsin-Fu Chen; Shee-Uan Chen; Hong-Nerng Ho; Yu-Shih Yang

doi:10.1016/j.fertnstert.2006.02.121

Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles

Fertil Steril. 2006 Oct;86(4):1020-2. doi: 10.1016/j.fertnstert.2006.02.121. Epub 2006 Sep 11.

Authors

Tsung-Hsien Lee¹, Ming-Yih Wu, Hsin-Fu Chen, Shee-Uan Chen, Hong-Nerng Ho, Yu-Shih Yang

Affiliation

¹ Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.

PMID: 16963037
DOI: 10.1016/j.fertnstert.2006.02.121

Abstract

The patients undertaking a single-dose protocol for GnRH antagonist were associated with elevated serum and follicular levels of nitric oxide (NO) and decreased embryo quality scores compared with those who underwent the long protocol for GnRH agonist. The relatively poor embryo quality may be NO related instead of Fas related.

Publication types

Controlled Clinical Trial

MeSH terms

Dose-Response Relationship, Drug
Embryo, Mammalian / cytology*
Embryo, Mammalian / drug effects
Embryo, Mammalian / metabolism*
Female
Fertilization in Vitro*
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Gonadotropin-Releasing Hormone / metabolism
Hormone Antagonists / administration & dosage*
Humans
Nitric Oxide / blood*
Ovarian Follicle / cytology
Ovarian Follicle / drug effects
Ovarian Follicle / metabolism

Substances

Hormone Antagonists
Nitric Oxide
Gonadotropin-Releasing Hormone