Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum

Jie Liu; Kenji Kurashiki; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1016/j.bmc.2006.08.018

Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum

Bioorg Med Chem. 2006 Dec 15;14(24):8654-60. doi: 10.1016/j.bmc.2006.08.018. Epub 2006 Sep 8.

Authors

Jie Liu¹, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

Affiliation

¹ Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.

PMID: 16962782
DOI: 10.1016/j.bmc.2006.08.018

Abstract

In humans, 5alpha-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5alpha-reductase activity. The presence of the C-3 carbonyl group and of the C-26-alpha,beta-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.

MeSH terms

5-alpha Reductase Inhibitors*
Animals
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Female
Male
Microsomes, Liver / enzymology
Molecular Structure
Rats
Rats, Sprague-Dawley
Reishi / chemistry*
Structure-Activity Relationship
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

5-alpha Reductase Inhibitors
Enzyme Inhibitors
Triterpenes