Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes

Utpal Sharma; Stuti Srivastava; Michael Prakesch; Maya Sharma; Donald M Leek; Prabhat Arya

doi:10.1021/cc060056a

Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes

J Comb Chem. 2006 Sep-Oct;8(5):735-61. doi: 10.1021/cc060056a.

Authors

Utpal Sharma¹, Stuti Srivastava, Michael Prakesch, Maya Sharma, Donald M Leek, Prabhat Arya

Affiliation

¹ Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6.

PMID: 16961411
DOI: 10.1021/cc060056a

Abstract

The solution- and solid-phase synthesis to obtain several natural-product-like, tetrahydroquinoline-based, polycyclic derivatives were developed. In one approach, two derivatives (38 and 41) having an eight-membered unsaturated lactam were successfully obtained both in solution and on solid support.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemical synthesis
Alkaloids / chemistry*
Aminoquinolines / chemistry*
Combinatorial Chemistry Techniques*
Molecular Probes / chemical synthesis
Molecular Probes / chemistry*
Polycyclic Compounds / chemical synthesis
Polycyclic Compounds / chemistry*
Solutions / chemistry
Stereoisomerism

Substances

Alkaloids
Aminoquinolines
Molecular Probes
Polycyclic Compounds
Solutions